663 Metastatic Parathyroid Cancer with Refractory Hypercalcaemia
نویسندگان
چکیده
منابع مشابه
Resistant hypercalcaemia in metastatic parathyroid carcinoma.
1 Department of Medical Oncology, We report a case of inoperable metastatic parathyroid carcinoma involving lifethreatening hypercalcaemia that failed to respond to standard therapy. Our review of available therapeutic modalities showed a paucity of evidence to guide management of patients with these rare tumours. This is the first report of the treatment of malignant hypercalcaemia secondary t...
متن کاملDenosumab for management of refractory hypercalcaemia in recurrent parathyroid carcinoma.
K Nadarasa, A Theodoraki, T R Kurzawinski, R Carpenter, J Bull, T T Chung and W M Drake Department of Endocrinology, St Bartholomew’s Hospital, London, UK, Department of Diabetes and Endocrinology, UCLH NHS Foundation Trust, London, UK, Department of Endocrine Surgery, UCLH NHS Foundation Trust, London, UK and Department of Neurosurgery, The Royal London Hospital, London, UK (K Nadarasa and A T...
متن کاملParathyroid hormone related protein and hypercalcaemia in breast cancer.
OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...
متن کاملRefractory hypercalcaemia secondary to parathyroid carcinoma: response to high-dose denosumab.
OBJECTIVE Hypercalcaemia is an important cause of increased morbidity and mortality in patients with parathyroid carcinoma. Surgical resection is the mainstay of treatment but, equally, managing hypercalcaemia is of paramount importance. At present, few therapies have been shown to be effective in the most severe cases. This report describes the efficacy of denosumab in a patient with parathyro...
متن کاملProlonged remission of hypercalcaemia due to parathyroid carcinoma with pamidronate.
Parathyroid carcinoma is rare and the associated hypercalcaemia is often resistant to all treatment. A case is described in which prolonged control of hypercalcaemia has been achieved by infrequent infusions of pamidronate despite continuing hypersecretion of parathyroid hormone.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: 0007-1323,1365-2168
DOI: 10.1093/bjs/znab134.312